Department of Microbiology and Immunology


Book Chapter

Leifer CA., JC Brooks. 2011. Regulation of Nucleic Acid Sensing Toll-like receptors in Systemic Lupus Erythematosus. Systemic Lupus Erythematosus. Edited by Hani Almoallim. Published by Intech. ISBN 978953-307-868-7.

Invited Reviews

Leifer, CA, WA Rose, F Botelho. 2013. Traditional biochemical assays for studying Toll-like receptor 9. Journal of Immunoassays and Immunochemistry. 34:1-15.

Peer-Reviewed Articles

Singh A, Rahman T, Malik M, Hickey AJ, Leifer CA, Hazlett KRO, Sellati TJ. 2013. Discordant Results Obtained with Francisella tularensis during In Vitro and In Vivo Immunological Studies Are Attributable to Compromised Bacterial Structural Integrity. PLoS One 8:e58513.

Lisa K. Scalfone, Hendrik J. Nel, Lucille F. Gagliardo, Jody L. Cameron, Shaikha Al-Shokri, Cynthia A. Leifer, Padraic G. Fallon, Judith A. Appleton. 2013. A prominent role for IL-33 in MyD88-dependent amplification of Th2 immunity and in controlling infection by a parasitic nematode. Infection and Immunity 81:1354-1363

Rose WA, K Sakamoto, CA Leifer. 2012. TLR9 is important for protection against intestinal damage and for intestinal repair. Scientific Reports 2:574.

Rose WA, K Sakamoto, CA Leifer. 2012. Multifunctional role of dextran sulfate sodium for in vivo modeling of intestinal diseases. BioMed Central Immunology 13:41.

Knežević J, 10, Pavlinić D, Rose III WA, Leifer CA, Bendelja K, Gabrilovac J, Parcina M, Lauc G, Kubarenko AV, Petricevic B, Vrbanec D, Bulat-Kardum L, Bekeredjian-Ding I, Pavelić J, Dembić Z, Weber ANR. 2012. Functional consequences of rare TLR9 gene mutation R892W. J Biol Chem 287:24544-24553.

Brooks J, W Sun, G Chiosis, CA Leifer. 2012. Heat shock protein gp96 regulates TLR9 proteolytic processing and conformational stability. Biochem Biophys Res Comm. 421:780-784.

Chockalingam A, WA Rose II, M Hasan, C Ju, CA Leifer. 2012. Cutting Edge: A Toll-like receptor 9 cytoplasmic tyrosine motif is selectively required for proinflammatory cytokine production. Journal of Immunology 188:527-530.

Hasan M, C Ruksznis, Y Wang, CA Leifer. 2011. Negative regulation of TLR3 signaling by an antimicrobial peptide. Journal of Immunology, 187: 5653-5659. *Evaluated by Faculty of 1000, which reviews the top 2% of published articles in biology and medicine.

Leifer CA and R Dietert. 2011. Developmental immunotoxicology and innate immunity. Toxicological and Environmental Chemistry. 93: 1463-1485.

Chockalingam A, J Brooks, J Cameron, CA Leifer. 2011. Negative regulation of Signaling by a Soluble Form of Toll-like receptor 9. European Journal of Immunology 41:2176-2184. *Featured by the Journal and in the Cornell Chronicle.

Ju CJ, A Chockalingam, JL Lopez, CA Leifer. 2009. Intestinal epithelial cells respond directly to Toxoplasma gondii and secrete inflammatory mediators via TLR2. J Immunol 183:7420-7427.

Bowdish DME, K Sakamoto, S Mukhopadhyay, CA Leifer, K Tryvaggson, S Gordon, DG Russell. 2009. Macrophage receptor with collagenous structure binds mycobacterial trehalose dimycolate and in concert with CD14, initiates TLR2 signaling. PLOS Pathogens 5(6):e1000474.

Chockalingam A, JC Brooks, JL Lopez, LK Blum, CA Leifer. 2009. TLR9 traffics through the Golgi to localize to endolysosomes and respond to CpG DNA. Immunol Cell Biol 87:209-217.

Dubey JP,GV Velmurugana, A Chockalingam, HF Pena, L Nunes de Oliveira, CA Leifer, SM Gennari, LMG Bahia Oliveira, C Su. 2008. Genetic diversity of Toxoplasma gondii isolates from chickens from Brazil. Vet Parasitol 157:299-305.

Semnani RT, Goel P, CA Leifer, S Mostböck, H Sabzevari, TB Nutman. 2008. Inhibition of TLR3 and TLR4 function and expression in human dendritic cells by helminth parasites. Blood 112: 1290-1298.

Leifer CA*, JC Brooks, K Hoelzer, JL Lopez, MN Kennedy, A Mazzoni, DM Segal. 2006. Cytoplasmic targeting motifs control localization of Toll-like receptor 9. J Biol Chem 281: 35585-35592.*This work was conceived and initiated as a postdoctoral fellow, but the bulk of the experiments and work was performed at Cornell with a Graduate Student (JCB), a rotation student (KH) and a technician (JLL). I served as the corresponding author.

Work performed prior to arrival at Cornell:

Mazzoni A, RP Siraganian, CA Leifer, DM Segal. 2006. Dendritic cell modulation by mast cells controls the Th1/Th2 balance in responding T cells. J Immunol 177: 3577-3581.

Wang ZY, D Yang, Q Chen, CA Leifer, DM Segal, SB Su, RR Caspi, ZO Howard, JJ Oppenheim. 2006. Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways. Exp Hematol 34:1115-1124.

Bafica, A., CA Scanga, CG Feng, CA Leifer, A Cheever, A Sher. 2005. TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis. J Exp Med 202:17151724.

Leifer CA, MN Kennedy, A Mazzoni, CW Lee, MJ Kruhlak, DM Segal. 2004. TLR9 is localized in the ER prior to stimulation. J Immunol 173: 1179-1183.

Kennedy MN, GED Mullen, CA Leifer, CW Lee, A Mazzoni, KN Dileepan, DM Segal. 2004. A complex of soluble MD2 and lipopolysaccharide serves as an activating ligand for Toll-like receptor 4. J Biol Chem 279: 34698-34704.

Bell JK, GED Mullen, CA Leifer, A Mazzoni, DR Davies, DM Segal. 2003. Leucine-rich repeats and pathogen recognition in Toll-like receptors. Trends Immunol 24: 528-533.

Huang LY, J Aliberti, CA Leifer, DM Segal, A Sher, DT Golenbock, B Golding. 2003 Heat-killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent pathways: TNF, unlike IL-12p40 secretion, is Toll-like receptor 2 dependent. J Immunol 171: 1441-1446.

Leifer CA, D Verthelyi, DM Klinman. 2003. Heterogeneity in the human response to immunostimulatory CpG Oligodeoxynucleotides. J Immunotherapy 26: 313-319.

Mullen GE, MN Kennedy, A Visintin, A Mazzoni, CA Leifer, DR Davies, DM Segal. 2003. The role of disulfide bonds in the assembly and function of MD-2. Proc Natl Acad Sci USA 100: 3919-3924.

Mazzoni A, CA Leifer, GE Mullen, MN Kennedy, DM Klinman, DM Segal. 2003. Cutting Edge: Histamine Inhibits IFN-alpha Release from Plasmacytoid Dendritic Cells. J Immunol 170: 2269-2273.

Biragyn A, PA Ruffini, CA Leifer, E Klyushnenkova, A Shakhov, O Chertoc, AK Shirakawa, JM Farber, DM Segal, JJ Oppenheim, LW Kwak. 2002. Toll-Like receptor 4-dependent activation of dendritic cells by betadefensin 2. Science 298: 1025-1029.

Klinman DM, F Takeshitsa, I Gursel, C Leifer, KJ Ishii, D Verthelyi, M Gursel. 2002. CpG DNA: Recognition by and activation of monocytes. Microbes Infect 4: 897-901.

Takeshita F*, CA Leifer*, I Gursel, KJ Ishii, S Takeshita, M Gursel, DM Klinman. 2001. Cutting edge: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells. J Immunol 167: 3555-3558 *co-first author.

Under maiden name Byrd

Byrd-Leifer CA, EF Block, K Takeda, S Akira, A Ding. 2001. The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol. Eur J Immunol 31: 2448-2457.

Byrd C, W Bornmann, H Erdjument-Bromage, P Tempst, N Pavletich, N Rosen, C Nathan, A Ding. 1999. Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide. Proc Natl Acad Sci USA 96: 5645-5650.

Zizi M, C Byrd, R Boxus, and M Colombini. 1998. The voltage-gating process of the voltage-dependent anion channel is sensitive to ion flow. Biophysical J 75: 704-713.

Gulbins E, R Bissonnette, A Mahboubi, S Martin, W Nishioka, T Brunner, G Baier, G Baier-Bitterlich, C Byrd, F Lang, R Kolesnick, A Altman, and D Green. 1995. Fas-induced apoptosis is mediated via a ceramideinitiated RAS signaling pathway. Immunity 2: 341-351.